In early July, the U.S. Drug Enforcement Administration (DEA) announced its intent to temporarily classify concentrated and synthetic 7-hydroxymitragynine (7-OH) products, along with related compounds mitragynine pseudoindoxyl (MP), MGM-15, and MGM-16, as Schedule I controlled substances. This action was taken due to concerns about abuse and public safety, as these substances can produce effects similar to opioids. Simultaneously, Texas strengthened its regulations on high-potency 7-OH products, while continuing to regulate traditional kratom separately.
7-OH is a chemical naturally found in the kratom plant, though typically only in tiny amounts. Many products sold today, often seen in smoke shops, vape stores, convenience stores, or online, differ significantly. Instead of traditional kratom leaf, they contain highly concentrated or synthetic forms of 7-OH, sometimes including related compounds like MP, MGM-15, or MGM-16. These concentrated products are notably more potent than traditional kratom and carry substantial risks.
The regulatory changes by federal and state authorities are expected to impact the availability of these products, making some harder to find. Healthcare professionals anticipate that these changes may lead more people to seek medical care if they experience withdrawal symptoms after discontinuing use.
Repeated use of concentrated 7-OH products can lead to physical dependence, much like other opioid-like substances. Individuals who stop using them suddenly may experience a range of withdrawal symptoms. These can include muscle aches, nausea, vomiting, diarrhea, sweating, chills, irritability, anxiety, and sleeplessness. While withdrawal can be uncomfortable, healthcare professionals confirm that help is available to discuss safe treatment options and make the process more manageable.
Despite being sold over the counter, high-potency 7-OH products are not always safe, contrary to common assumptions. These products have been linked to serious medical issues, including severe breathing problems, unconsciousness, and in some cases, cardiac arrest. Medical reports indicate that naloxone, also known as Narcan, can effectively reverse these opioid-like effects, similar to its action in other opioid overdoses.
In emergency situations, if someone becomes difficult to wake up, stops breathing normally, or becomes unresponsive after using one of these products, it is critical to call 911 immediately. If naloxone is available, administering it while waiting for emergency medical services is advised.
For those experiencing difficulty stopping the use of 7-OH products, treatment options are available. The Addiction Medicine team at UT Health East Texas provides compassionate, evidence-based care for individuals struggling with dependence on 7-OH, kratom-related products, and other substances. Treatment approaches may include medications to reduce withdrawal symptoms, counseling, and ongoing support to aid in safe recovery. Though often marketed as natural or safer alternatives, concentrated 7-OH products function much like opioids and pose genuine risks, including physical dependence, withdrawal, and overdose.
