Grand Rounds: "Breast Cancer 2026: From Chemotherapy to Precision Therapeutics - The Rise of ADCs and ctDNA" Speaker: Kavitha Donthireddy, MD Assistant Professor, Internal Medicine Hematology Oncology Fellowship Program Director UT Tyler School of Medicine Objectives: At the end of this presentation, participants should have increased information to: Review current breast cancer classification and molecular subtypesDiscuss biology and mechanisms of antibody-drug conjugates (ADCs)Discuss landmark clinical trials that changed breast cancer treatmentExplain the role of circulating tumor DNA (ctDNA) in early and metastatic breast cancerRecognize implications for internists regarding toxicity monitoring, survivorship and multidisciplinary careExplore future directions in personalized oncology.Grand Rounds are designed for physicians, residents, and medical students and are available to other healthcare professionals with an interest in the program being presented. The University of Texas at Tyler Health Science Center is accredited by the Texas Medical Association to provide continuing medical education for physicians. The University of Texas at Tyler Health Science Center designates this live educational activity for a maximum of 1.0 AMA PRA Category 1 creditTM. Participants should only claim credit commensurate with the extent of their participation in the activity. ABIM MOC Credit Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to one (1) MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.